A Johns Hopkins pilot study found that psilocybin, given with psychological support, was safe and well tolerated in adults with post-treatment Lyme disease and was associated with significant, lasting reductions in multi-system symptom burden, including improved mood, fatigue, sleep, pain, and quality of life for up to six months.

Cannabidiol (CBD), as one of the phytocannabinoids, has a wide range of therapeutic properties for various neuropsychiatric disorders due to central nervous system effects.

Kratom (Mitragyna speciosa) is a tropical plant traditionally used as an ethnomedicinal remedy for several conditions in South East Asia. Despite the increased interest in its therapeutical benefits in Western countries, little scientific evidence is available to support such claims, and existing data remain limited to kratom's chronic consumption.